FUSIDIC ACID

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: Parent
ATC: D06AX01
UNII: 59XE10C19C

Structure
InChI Key IECPWNUMDGFDKC-MZJAQBGESA-N
Smile CC(=O)O[C@H]1C[C@@]2(C)[C@@H](C[C@@H](O)[C@H]3[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]32C)/C1=C(\CCC=C(C)C)C(=O)O
InChI
InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C31H48O6
Molecular Weight 516.72
AlogP 5.67
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 5.0
Polar Surface Area 104.06
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 37.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Elongation factor G inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Secreted protein
- - 12000 - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 40
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 10100-11500 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Keloid 3 D007627 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Infections 2 D007239 ClinicalTrials
Skin Diseases 2 D012871 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 6990-06-3
ChEBI 29013
ChEMBL CHEMBL374975
DrugBank DB02703
DrugCentral 1261
EPA CompTox DTXSID0023086
FDA SRS 59XE10C19C
Human Metabolome Database HMDB0015570
Guide to Pharmacology 10815
PDB FUA
PharmGKB PA164749648
PubChem 3000226
SureChEMBL SCHEMBL25646
ZINC ZINC000008143796
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