GALANTAMINE

Search structure
Synonyms:
Status: Approved (2001)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N06DA04
UNII: 0D3Q044KCA

Structure
InChI Key ASUTZQLVASHGKV-JDFRZJQESA-N
Smile COc1ccc2c3c1O[C@H]1C[C@@H](O)C=C[C@@]31CCN(C)C2
InChI
InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H21NO3
Molecular Weight 287.36
AlogP 1.85
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 1.0
Polar Surface Area 41.93
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 21.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
1100 100-1725000 - 192.47-28290 0.6-100
Enzyme Oxidoreductase
5.06 - - - -
Enzyme Transferase
- - - - 9.86-19.34
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -31.78-2.81
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor epsilon subunit
- 0.767 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder 3 D003866 ClinicalTrials
Alzheimer Disease 3 D000544 ClinicalTrials
Schizophrenia 3 D012559 ClinicalTrials
Lewy Body Disease 3 D020961 ClinicalTrials
Autistic Disorder 3 D001321 ClinicalTrials
Dementia, Vascular 3 D015140 ClinicalTrials
Anxiety 3 D001007 ClinicalTrials
Cocaine-Related Disorders 2 D019970 ClinicalTrials
HIV Infections 2 D015658 ClinicalTrials
Tobacco Use Disorder 2 D014029 ClinicalTrials
Psychotic Disorders 2 D011618 ClinicalTrials
Memory 1 D008568 ClinicalTrials
Obesity 1 D009765 ClinicalTrials
Subarachnoid Hemorrhage 1 D013345 ClinicalTrials
Hypotension, Orthostatic 1 D007024 ClinicalTrials
Lecithin Cholesterol Acyltransferase Deficiency 1 D007863 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 357-70-0
ChEBI 42944
ChEMBL CHEMBL659
DrugBank DB00674
DrugCentral 1272
EPA CompTox DTXSID2045606
FDA SRS 0D3Q044KCA
Human Metabolome Database HMDB14812
Guide to Pharmacology 6693
KEGG C08526
PDB GNT
PharmGKB PA449726
PubChem 9651
SureChEMBL SCHEMBL2577
ZINC ZINC000000491073
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