DrugMapper

Search structure


InChI Key	RVAQIUULWULRNW-UHFFFAOYSA-N
Smile	CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O
InChI	InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)

Action	Mechanism of Action	Reference
INHIBITOR	Heat shock protein HSP90 inhibitor	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Other cytosolic protein	-	38-51	23565	-	-
Other membrane protein	-	10	-	-	-

Mesh Heading	Maximum Phase	Mesh ID	Reference
Adenocarcinoma of Lung	3	D000077192	ClinicalTrials
Carcinoma, Non-Small-Cell Lung	2	D002289	ClinicalTrials
Hemangiosarcoma	2	D006394	ClinicalTrials
Stomach Neoplasms	2	D013274	ClinicalTrials
Prostatic Neoplasms	2	D011471	ClinicalTrials
Breast Neoplasms	2	D001943	ClinicalTrials
Melanoma	2	D008545	ClinicalTrials
Gastrointestinal Stromal Tumors	2	D046152	ClinicalTrials
Colonic Neoplasms	2	D003110	ClinicalTrials
Rectal Neoplasms	2	D012004	ClinicalTrials
Small Cell Lung Carcinoma	2	D055752	ClinicalTrials
Lung Neoplasms	1	D008175	ClinicalTrials
Esophageal Neoplasms	1	D004938	ClinicalTrials
Neoplasms	1	D009369	ClinicalTrials
Mesothelioma	1	D008654	ClinicalTrials
Carcinoma, Hepatocellular	1	D006528	ClinicalTrials
Myelodysplastic Syndromes	1	D009190	ClinicalTrials
Leukemia, Myeloid, Acute	1	D015470	ClinicalTrials
Multiple Myeloma	1	D009101	ClinicalTrials
Breast Neoplasms, Male	1	D018567	ClinicalTrials
Neurilemmoma	1	D009442	ClinicalTrials
Fallopian Tube Neoplasms	1	D005185	ClinicalTrials
Ovarian Neoplasms	1	D010051	ClinicalTrials

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Level 6

Indication

Mechanism of Action

Primary Target

Target Level

GANETESPIB


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70