IDALOPIRDINE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 59WCJ0YNWM

Structure
InChI Key YBAWYTYNMZWMMJ-UHFFFAOYSA-N
Smile Fc1ccc2c(CCNCc3cccc(OCC(F)(F)C(F)F)c3)c[nH]c2c1
InChI
InChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H19F5N2O
Molecular Weight 398.38
AlogP 4.92
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 9.0
Polar Surface Area 37.05
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Serotonin 6 (5-HT6) receptor antagonist PubMed Other
Primary Target
5-HT6 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 6
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- - - 1215 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- 1000 - 1-7 88-106

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alzheimer Disease 3 D000544 ClinicalTrials
Schizophrenia 2 D012559 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 467459-31-0
ChEMBL CHEMBL3286580
DrugBank DB11957
FDA SRS 59WCJ0YNWM
Guide to Pharmacology 8689
PubChem 21071390
SureChEMBL SCHEMBL762762
ZINC ZINC000095936819
CONTENTS