IMG-7289

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: Y2T4ALDEAT

Structure
InChI Key KQKBMHGOHXOHTD-KKUQBAQOSA-N
Smile CN1CCN(C(=O)[C@H](CCCN[C@@H]2C[C@H]2c2ccc(F)cc2)NC(=O)c2ccc(-n3ccnn3)cc2)CC1
InChI
InChI=1S/C28H34FN7O2/c1-34-15-17-35(18-16-34)28(38)25(3-2-12-30-26-19-24(26)20-4-8-22(29)9-5-20)32-27(37)21-6-10-23(11-7-21)36-14-13-31-33-36/h4-11,13-14,24-26,30H,2-3,12,15-19H2,1H3,(H,32,37)/t24-,25-,26+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C28H34FN7O2
Molecular Weight 519.63
AlogP 2.2
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 10.0
Polar Surface Area 95.39
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 38.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Lysine-specific histone demethylase 1 inhibitor Other PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Thrombocythemia, Essential 2 D013920 ClinicalTrials
Myelodysplastic Syndromes 1 D009190 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1990504-34-1
ChEMBL CHEMBL4297289
DrugBank DB15126
FDA SRS Y2T4ALDEAT
SureChEMBL SCHEMBL17984236
CONTENTS