IMG-7289

Search structure


Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	Y2T4ALDEAT

Structure


InChI Key	KQKBMHGOHXOHTD-KKUQBAQOSA-N
Smile	CN1CCN(C(=O)[C@H](CCCN[C@@H]2C[C@H]2c2ccc(F)cc2)NC(=O)c2ccc(-n3ccnn3)cc2)CC1
InChI	InChI=1S/C28H34FN7O2/c1-34-15-17-35(18-16-34)28(38)25(3-2-12-30-26-19-24(26)20-4-8-22(29)9-5-20)32-27(37)21-6-10-23(11-7-21)36-14-13-31-33-36/h4-11,13-14,24-26,30H,2-3,12,15-19H2,1H3,(H,32,37)/t24-,25-,26+/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C28H34FN7O2
Molecular Weight	519.63
AlogP	2.2
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	10.0
Polar Surface Area	95.39
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	38.0

Indications

Mesh Heading	Maximum Phase	Reference
Myelodysplastic Syndromes	Phase 1	ClinicalTrials
Polycythemia; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential; Thrombocytosis	Phase 2	ClinicalTrials

Cross References

Resources	Reference
CAS NUMBER	1990504-34-1
ChEMBL	CHEMBL4297289
DrugBank	DB15126
FDA SRS	Y2T4ALDEAT
SureChEMBL	SCHEMBL17984236

CONTENTS