IMPLITAPIDE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: Q70OH404HR

Structure
InChI Key AMNXBQPRODZJQR-DITALETJSA-N
Smile Cc1cc(C)c2c3ccccc3n(Cc3cccc([C@@H](C(=O)N[C@@H](CO)c4ccccc4)C4CCCC4)c3)c2n1
InChI
InChI=1S/C35H37N3O2/c1-23-19-24(2)36-34-32(23)29-17-8-9-18-31(29)38(34)21-25-11-10-16-28(20-25)33(27-14-6-7-15-27)35(40)37-30(22-39)26-12-4-3-5-13-26/h3-5,8-13,16-20,27,30,33,39H,6-7,14-15,21-22H2,1-2H3,(H,37,40)/t30-,33-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C35H37N3O2
Molecular Weight 531.7
AlogP 6.98
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 8.0
Polar Surface Area 67.15
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 40.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Microsomal triglyceride transfer protein inhibitor PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hypertriglyceridemia 2 D015228 ClinicalTrials
Hyperlipoproteinemia Type II 2 D006938 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 177469-96-4
ChEMBL CHEMBL2105804
DrugBank DB04852
FDA SRS Q70OH404HR
PubChem 5745206
SureChEMBL SCHEMBL1650033
ZINC ZINC000059676426
CONTENTS