IXAZOMIB

Search structure
Synonyms:
Status: Approved (2015)
Entry Type: Small molecule
Molecule Category: Parent
ATC: L01XG03
UNII: 71050168A2

Structure
InChI Key MXAYKZJJDUDWDS-LBPRGKRZSA-N
Smile CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
InChI
InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H19BCl2N2O4
Molecular Weight 361.03
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR 26S proteasome inhibitor EMA PubMed PubMed
Primary Target
proteasome 20S subunit beta 5
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Protease Serine protease Serine protease SK clan Serine protease S14 family
3600 5300 - - -
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1A subfamily
- 3-9 - - -
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1B subfamily
- 15 - - -
Other cytosolic protein
- 6 - - -
Transcription factor
- 6 - - -
Unclassified protein
- 15 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Plasmacytoma 3 D010954 ClinicalTrials
Amyloidosis, Familial 3 D028226 ClinicalTrials
Multiple Myeloma 3 D009101 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Lymphoma, Mantle-Cell 2 D020522 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Renal Insufficiency, Chronic 2 D051436 ClinicalTrials
Waldenstrom Macroglobulinemia 2 D008258 ClinicalTrials
Purpura, Thrombocytopenic, Idiopathic 2 D016553 ClinicalTrials
Anemia, Hemolytic, Autoimmune 2 D000744 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Carcinoma, Renal Cell 1 D002292 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Lymphoma 1 D008223 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Triple Negative Breast Neoplasms 1 D064726 ClinicalTrials
Lupus Nephritis 1 D008181 ClinicalTrials
HIV Infections 1 D015658 ClinicalTrials

Related Entries

Salt

Cross References

Resources Reference
CAS NUMBER 1072833-77-2
ChEBI 90942
ChEMBL CHEMBL2141296
DrugBank DB09570
DrugCentral 5067
FDA SRS 71050168A2
Guide to Pharmacology 8450
PDB 6V8
PubChem 25183872
SureChEMBL SCHEMBL3742758
ZINC ZINC000169946773
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