JNJ-18038683

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 28PGH5X4OQ

Structure
InChI Key UKJPMZGILXATGT-UHFFFAOYSA-N
Smile Clc1ccc(-c2nn(Cc3ccccc3)c3c2CCNCC3)cc1
InChI
InChI=1S/C20H20ClN3/c21-17-8-6-16(7-9-17)20-18-10-12-22-13-11-19(18)24(23-20)14-15-4-2-1-3-5-15/h1-9,22H,10-14H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H20ClN3
Molecular Weight 337.85
AlogP 3.94
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 29.85
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Serotonin 7 (5-HT7) receptor antagonist PubMed
Primary Target
5-HT7 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- - - 6-316 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Bipolar Disorder 2 D001714 ClinicalTrials
Depressive Disorder, Major 2 D003865 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4205783
FDA SRS 28PGH5X4OQ
Guide to Pharmacology 8432
PubChem 11249539
SureChEMBL SCHEMBL2076477
ChEMBL CHEMBL4297293
FDA SRS 9UKQ1NQ8YX
Guide to Pharmacology 8432
PubChem 11249539
SureChEMBL SCHEMBL2076923
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