JNJ-38877605

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 15UDG410PN

Structure
InChI Key JRWCBEOAFGHNNU-UHFFFAOYSA-N
Smile Cn1cc(-c2ccc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1
InChI
InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H13F2N7
Molecular Weight 377.36
AlogP 3.21
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 73.79
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Hepatocyte growth factor receptor inhibitor Other PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family
- 1-10 - - 71-72
Unclassified protein
- 9 - - 71-72

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 1 D009369 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 943540-75-8
ChEBI 91417
ChEMBL CHEMBL2133806
DrugBank DB13113
EPA CompTox DTXSID20677253
FDA SRS 15UDG410PN
PubChem 46911863
SureChEMBL SCHEMBL182199
ZINC ZINC000043170515
CONTENTS