KZR-616

Search structure


Synonyms:	Kzr-616 Zetomipzomib
Status:	Phase 2
Entry Type:	Protein
Molecule Category:	UNKNOWN
UNII:	O4BT6C02M2

Structure


InChI Key	GHYOCDFICYLMRF-UTIIJYGPSA-N
Smile	COc1ccc([C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@@]2(C)CO2)cc1
InChI	InChI=1S/C30H42N4O8/c1-19(31-24(35)17-34-12-14-41-15-13-34)28(38)33-25(26(36)21-8-10-22(40-3)11-9-21)29(39)32-23(16-20-6-4-5-7-20)27(37)30(2)18-42-30/h6,8-11,19,23,25-26,36H,4-5,7,12-18H2,1-3H3,(H,31,35)(H,32,39)(H,33,38)/t19-,23-,25-,26+,30+/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C30H42N4O8
Molecular Weight	586.69
AlogP	0.39
Hydrogen Bond Acceptor	9.0
Hydrogen Bond Donor	4.0
Number of Rotational Bond	14.0
Polar Surface Area	158.83
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	42.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	522	-	-	-
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1A subfamily	-	0-39	-	-	-
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1B subfamily	-	1-131	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Dermatomyositis	2	D003882	ClinicalTrials
Purpura, Thrombocytopenic, Idiopathic	2	D016553	ClinicalTrials
Anemia, Hemolytic, Autoimmune	2	D000744	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL4297468
DrugBank	DB16070
FDA SRS	O4BT6C02M2
Guide to Pharmacology	10409
PubChem	117607904
SureChEMBL	SCHEMBL16118957

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