LADARIXIN

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: DEH7Q6472O

Structure
InChI Key DDLPYOCJHQSVSZ-SSDOTTSWSA-N
Smile C[C@@H](C(=O)NS(C)(=O)=O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1
InChI
InChI=1S/C11H12F3NO6S2/c1-7(10(16)15-22(2,17)18)8-3-5-9(6-4-8)21-23(19,20)11(12,13)14/h3-7H,1-2H3,(H,15,16)/t7-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H12F3NO6S2
Molecular Weight 375.35
AlogP 1.09
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 106.61
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 23.0

Pharmacology

Action Mechanism of Action Reference
MODULATOR Interleukin-8 receptor A modulator PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetes Mellitus, Type 1 3 D003922 ClinicalTrials
Pemphigoid, Bullous 2 D010391 ClinicalTrials

Related Entries

MCS

Cross References

Resources Reference
ChEMBL CHEMBL189475
DrugBank DB16212
EPA CompTox DTXSID50234030
FDA SRS DEH7Q6472O
PubChem 11372270
SureChEMBL SCHEMBL251618
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