LAROMUSTINE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 14J2G0U3NQ

Structure
InChI Key PVCULFYROUOVGJ-UHFFFAOYSA-N
Smile CNC(=O)N(N(CCCl)S(C)(=O)=O)S(C)(=O)=O
InChI
InChI=1S/C6H14ClN3O5S2/c1-8-6(11)10(17(3,14)15)9(5-4-7)16(2,12)13/h4-5H2,1-3H3,(H,8,11)

Physicochemical Descriptors

Property Name Value
Molecular Formula C6H14ClN3O5S2
Molecular Weight 307.78
AlogP -1.0
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 103.86
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 17.0

Pharmacology

Action Mechanism of Action Reference
CROSS-LINKING AGENT DNA cross-linking agent PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Leukemia 3 D007938 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Myelodysplastic Syndromes 1 D009190 ClinicalTrials
Lymphoma 1 D008223 ClinicalTrials
Central Nervous System Neoplasms 1 D016543 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 173424-77-6
ChEMBL CHEMBL167691
DrugBank DB05817
EPA CompTox DTXSID30169614
FDA SRS 14J2G0U3NQ
PubChem 3081349
SureChEMBL SCHEMBL2416976
ZINC ZINC000001544545
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