LEVOMILNACIPRAN

Search structure
Synonyms:
Status: Approved (2013)
Entry Type: Small molecule
Molecule Category: Parent
UNII: UGM0326TXX

Structure
InChI Key GJJFMKBJSRMPLA-DZGCQCFKSA-N
Smile CCN(CC)C(=O)[C@@]1(c2ccccc2)C[C@H]1CN
InChI
InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H22N2O
Molecular Weight 246.35
AlogP 1.77
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 46.33
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 18.0

Pharmacology

Primary Target
NET
SERT
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor
- 6300-6300 - - 53
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 3200-3200 - 9-9 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder, Major 3 D003865 ClinicalTrials
Tobacco Use Disorder 0 D014029 ClinicalTrials

Related Entries

MCS

Salt

Cross References

Resources Reference
CAS NUMBER 96847-54-0
ChEBI 136040
ChEMBL CHEMBL99946
DrugBank DB08918
DrugCentral 4864
FDA SRS UGM0326TXX
Guide to Pharmacology 7435
PubChem 6917779
SureChEMBL SCHEMBL1414867
ZINC ZINC000000000506
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