LIAROZOLE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 17NYD2210B

Structure
InChI Key UGFHIPBXIWJXNA-UHFFFAOYSA-N
Smile Clc1cccc(C(c2ccc3nc[nH]c3c2)n2ccnc2)c1
InChI
InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H13ClN4
Molecular Weight 308.77
AlogP 4.05
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 46.5
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 22.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 19 Cytochrome P450 family 19A Cytochrome P450 19A1
- 5-45 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6
- 4760 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 24 Cytochrome P450 family 24A Cytochrome P450 24A1
- 2 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 26 Cytochrome P450 family 26A Cytochrome P450 26A1
- 540-7000 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 26
- 540-7000 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4
- 690 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Ichthyosis, Lamellar 2 D017490 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 115575-11-6
ChEBI 135316
ChEMBL CHEMBL389433
DrugBank DB13066
EPA CompTox DTXSID9048277
FDA SRS 17NYD2210B
Guide to Pharmacology 5210
PubChem 60652
SureChEMBL SCHEMBL18597
CONTENTS