Synonyms: | |
Status: | Approved (1995) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | C09CA01 |
UNII: | JMS50MPO89 |
InChI Key | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
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Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C22H23ClN6O |
Molecular Weight | 422.92 |
AlogP | 4.27 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 8.0 |
Polar Surface Area | 92.51 |
Molecular species | ACID |
Aromatic Rings | 4.0 |
Heavy Atoms | 30.0 |
Primary Target | |
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AT1 receptor |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Diabetic Nephropathies | 3 | D003928 | ClinicalTrials |
Glioblastoma | 3 | D005909 | ClinicalTrials |
Hypertension | 3 | D006973 | ClinicalTrials |
Severe Acute Respiratory Syndrome | 3 | D045169 | ClinicalTrials |
Kidney Diseases | 3 | D007674 | ClinicalTrials |
Heart Failure | 3 | D006333 | ClinicalTrials |
Renal Insufficiency, Chronic | 3 | D051436 | ClinicalTrials |
Glomerulonephritis, IGA | 3 | D005922 | ClinicalTrials |
Non-alcoholic Fatty Liver Disease | 3 | D065626 | ClinicalTrials |
Essential Hypertension | 3 | D000075222 | ClinicalTrials |
Proteinuria | 3 | D011507 | ClinicalTrials |
Hyperoxaluria, Primary | 3 | D006960 | ClinicalTrials |
Marfan Syndrome | 3 | D008382 | ClinicalTrials |
Severe Acute Respiratory Syndrome | 3 | D045169 | ClinicalTrials |
Hypertension, Pulmonary | 3 | D006976 | ClinicalTrials |
Hypertrophy, Left Ventricular | 3 | D017379 | ClinicalTrials |
Diabetes Mellitus, Type 1 | 2 | D003922 | ClinicalTrials |
Pancreatic Neoplasms | 2 | D010190 | ClinicalTrials |
Sarcopenia | 2 | D055948 | ClinicalTrials |
Respiratory Distress Syndrome | 2 | D012128 | ClinicalTrials |
Cystic Fibrosis | 2 | D003550 | ClinicalTrials |
Inflammation | 2 | D007249 | ClinicalTrials |
Glomerulosclerosis, Focal Segmental | 2 | D005923 | ClinicalTrials |
Anemia, Sickle Cell | 2 | D000755 | ClinicalTrials |
Cardiomyopathy, Hypertrophic | 2 | D002312 | ClinicalTrials |
HIV Infections | 2 | D015658 | ClinicalTrials |
Idiopathic Pulmonary Fibrosis | 2 | D054990 | ClinicalTrials |
Stress Disorders, Post-Traumatic | 2 | D013313 | ClinicalTrials |
Constriction, Pathologic | 1 | D003251 | ClinicalTrials |
Melanoma | 1 | D008545 | ClinicalTrials |
Aging | 1 | D000375 | ClinicalTrials |
Wounds and Injuries | 1 | D014947 | ClinicalTrials |
Osteoarthritis, Knee | 1 | D020370 | ClinicalTrials |
Diabetes Mellitus, Type 2 | 1 | D003924 | ClinicalTrials |
Osteosarcoma | 1 | D012516 | ClinicalTrials |
Peripheral Arterial Disease | 0 | D058729 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 114798-26-4 |
ChEBI | 6541 |
ChEMBL | CHEMBL191 |
DrugBank | DB00678 |
DrugCentral | 1610 |
EPA CompTox | DTXSID7023227 |
FDA SRS | JMS50MPO89 |
Human Metabolome Database | HMDB0014816 |
Guide to Pharmacology | 590 |
KEGG | C07072 |
PDB | LSN |
PharmGKB | PA450268 |
PubChem | 3961 |
SureChEMBL | SCHEMBL60 |
ZINC | ZINC000003873160 |