LOSMAPIMOD

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: F2DQF16BXE

Structure
InChI Key KKYABQBFGDZVNQ-UHFFFAOYSA-N
Smile Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cn1
InChI
InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H26FN3O2
Molecular Weight 383.47
AlogP 3.86
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 71.09
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR MAP kinase p38 alpha inhibitor PubMed PubMed
Primary Target
mitogen-activated protein kinase 14
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9
- 31623 - - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase p38 subfamily
- 25-100 - 8-63 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Acute Coronary Syndrome 3 D054058 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Neuralgia 2 D009437 ClinicalTrials
Glomerulosclerosis, Focal Segmental 2 D005923 ClinicalTrials
Pulmonary Disease, Chronic Obstructive 2 D029424 ClinicalTrials
Atherosclerosis 2 D050197 ClinicalTrials
Arthritis, Rheumatoid 2 D001172 ClinicalTrials
Lipid Metabolism Disorders 2 D052439 ClinicalTrials
Muscular Dystrophy, Facioscapulohumeral 2 D020391 ClinicalTrials
Depressive Disorder, Major 2 D003865 ClinicalTrials
Cardiovascular Diseases 1 D002318 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 585543-15-3
ChEBI 131167
ChEMBL CHEMBL1088752
DrugBank DB12270
FDA SRS F2DQF16BXE
Guide to Pharmacology 7835
PubChem 11552706
SureChEMBL SCHEMBL1070401
ZINC ZINC000035793138
CONTENTS