MACIMORELIN

Search structure
Synonyms:
Status: Approved (2017)
Entry Type: Small molecule
Molecule Category: Parent
ATC: V04CD06
UNII: 8680B21W73

Structure
InChI Key UJVDJAPJQWZRFR-DHIUTWEWSA-N
Smile CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O
InChI
InChI=1S/C26H30N6O3/c1-26(2,27)25(35)31-22(11-16-13-28-20-9-5-3-7-18(16)20)24(34)32-23(30-15-33)12-17-14-29-21-10-6-4-8-19(17)21/h3-10,13-15,22-23,28-29H,11-12,27H2,1-2H3,(H,30,33)(H,31,35)(H,32,34)/t22-,23-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C26H30N6O3
Molecular Weight 474.57
AlogP 1.84
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 6.0
Number of Rotational Bond 10.0
Polar Surface Area 144.9
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 35.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Ghrelin receptor agonist PubMed PubMed Other Wikipedia
Primary Target
ghrelin receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) GRP-related receptor
- 23-123 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cachexia 2 D002100 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 381231-18-1
ChEMBL CHEMBL278623
DrugBank DB13074
FDA SRS 8680B21W73
Guide to Pharmacology 9745
PubChem 9804938
SureChEMBL SCHEMBL1984708
ZINC ZINC000001554197
CONTENTS