| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | B5TRY67L51 |
Structure
| InChI Key | NFTMKHWBOINJGM-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H24N8OS |
| Molecular Weight | 448.56 |
| AlogP | 3.43 |
| Hydrogen Bond Acceptor | 10.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 94.74 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 32.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| AGONIST | Glucose-dependent insulinotropic receptor agonist | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | - | - | - | 11 | |
|
Membrane receptor
Family A G protein-coupled receptor
Small molecule receptor (family A GPCR)
Lipid-like ligand receptor (family A GPCR)
|
4-5000 | - | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Diabetes Mellitus | 2 | D003920 | ClinicalTrials |
| Diabetes Mellitus, Type 1 | 2 | D003922 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1037792-44-1 |
| ChEMBL | CHEMBL3260505 |
| DrugBank | DB12345 |
| EPA CompTox | DTXSID20146055 |
| FDA SRS | B5TRY67L51 |
| Guide to Pharmacology | 10166 |
| PubChem | 25025505 |
| SureChEMBL | SCHEMBL1118326 |
| ZINC | ZINC000073069252 |
CONTENTS