MEXILETINE

Search structure
Synonyms:
Status: Approved (1985)
Entry Type: Small molecule
Molecule Category: Parent
ATC: C01BB02
UNII: 1U511HHV4Z

Structure
InChI Key VLPIATFUUWWMKC-UHFFFAOYSA-N
Smile Cc1cccc(C)c1OCC(C)N
InChI
InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H17NO
Molecular Weight 179.26
AlogP 2.03
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 35.25
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 13.0

Pharmacology

Primary Target
Nav1.4
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Two-pore domain potassium channel
- 97300 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 10000 - - -
Ion channel Voltage-gated ion channel Voltage-gated calcium channel
- 100000 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 11000-56000 - 13000 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- - - - -3--1

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Myotonic Dystrophy 3 D009223 ClinicalTrials
Myotonic Dystrophy 3 D009223 ClinicalTrials
Myocardial Infarction 3 D009203 ClinicalTrials
Death, Sudden, Cardiac 3 D016757 ClinicalTrials
Ventricular Fibrillation 3 D014693 ClinicalTrials
Charcot-Marie-Tooth Disease 2 D002607 ClinicalTrials
Chronic Pain 2 D059350 ClinicalTrials
Blepharospasm 2 D001764 ClinicalTrials
Irritable Bowel Syndrome 1 D043183 ClinicalTrials

Related Entries

Salt

Cross References

Resources Reference
CAS NUMBER 31828-71-4
ChEBI 6916
ChEMBL CHEMBL558
DrugBank DB00379
DrugCentral 1794
EPA CompTox DTXSID8048446
FDA SRS 1U511HHV4Z
Human Metabolome Database HMDB0014523
Guide to Pharmacology 2629
KEGG C07220
PharmGKB PA450488
PubChem 4178
SureChEMBL SCHEMBL16081
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