MK-2206

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 51HZG6MP1K

Structure
InChI Key ULDXWLCXEDXJGE-UHFFFAOYSA-N
Smile NC1(c2ccc(-c3nc4ccn5c(=O)[nH]nc5c4cc3-c3ccccc3)cc2)CCC1
InChI
InChI=1S/C25H21N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31)

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H21N5O
Molecular Weight 407.48
AlogP 4.24
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 89.07
Molecular species BASE
Aromatic Rings 5.0
Heavy Atoms 31.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Serine/threonine-protein kinase AKT inhibitor PubMed Other
Primary Target
AKT serine/threonine kinase 1
AKT serine/threonine kinase 2
AKT serine/threonine kinase 3
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase AKT family
- 8-10 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Glioma 2 D005910 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Carcinoma, Renal Cell 2 D002292 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Adenocarcinoma, Bronchiolo-Alveolar 2 D002282 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Carcinoma, Large Cell 2 D018287 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 1 D015451 ClinicalTrials
Breast Neoplasms, Male 1 D018567 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 1 D002289 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 67271
ChEMBL CHEMBL1079175
EPA CompTox DTXSID3048948
FDA SRS 51HZG6MP1K
Guide to Pharmacology 7945
PubChem 67254077
SureChEMBL SCHEMBL530721
ZINC ZINC000036382821
CONTENTS