| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | H8J407531S |
Structure
| InChI Key | LCVIRAZGMYMNNT-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H21ClFN3O3S |
| Molecular Weight | 461.95 |
| AlogP | 5.71 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 84.34 |
| Molecular species | ACID |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 31.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Serine/threonine-protein kinase Aurora-A inhibitor | PubMed |
| Primary Target | |
|---|---|
| aurora kinase A |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 1 | D009369 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1010085-13-8 |
| ChEBI | 125340 |
| ChEMBL | CHEMBL3182444 |
| FDA SRS | H8J407531S |
| Guide to Pharmacology | 8061 |
| PubChem | 24748204 |
| SureChEMBL | SCHEMBL1501374 |
| ZINC | ZINC000073069245 |
CONTENTS