| Synonyms: | |
| Status: | Approved (1999) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | J01MA14 |
| UNII: | U188XYD42P |
Structure
| InChI Key | FABPRXSRWADJSP-MEDUHNTESA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C21H24FN3O4 |
| Molecular Weight | 401.44 |
| AlogP | 2.37 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 83.8 |
| Molecular species | ZWITTERION |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 29.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Isomerase
|
- | 6000-12500 | - | - | - | |
|
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | 79433 | - | - | 10-42 | |
|
Ion channel
Voltage-gated ion channel
Voltage-gated sodium channel
|
- | 39811 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Bacterial Infections | 4 | D001424 | ClinicalTrials |
| Eye Infections | 4 | D015817 | ClinicalTrials |
| Otitis Media | 3 | D010033 | ClinicalTrials |
| Cellulitis | 3 | D002481 | ClinicalTrials |
| Tuberculosis | 3 | D014376 | ClinicalTrials |
| Pneumonia | 3 | D011014 | ClinicalTrials |
| Abscess | 3 | D000038 | ClinicalTrials |
| Infections | 3 | D007239 | ClinicalTrials |
| Bronchitis, Chronic | 3 | D029481 | ClinicalTrials |
| Otitis Externa | 3 | D010032 | ClinicalTrials |
| Pneumonia, Bacterial | 3 | D018410 | ClinicalTrials |
| Conjunctivitis, Bacterial | 3 | D003234 | ClinicalTrials |
| Cataract | 3 | D002386 | ClinicalTrials |
| Breast Neoplasms | 3 | D001943 | ClinicalTrials |
| Endophthalmitis | 3 | D009877 | ClinicalTrials |
| Skin Diseases | 3 | D012871 | ClinicalTrials |
| Sinusitis | 3 | D012852 | ClinicalTrials |
| Tuberculosis, Pulmonary | 3 | D014397 | ClinicalTrials |
| Cholecystitis, Acute | 3 | D041881 | ClinicalTrials |
| Pelvic Inflammatory Disease | 3 | D000292 | ClinicalTrials |
| Inflammation | 3 | D007249 | ClinicalTrials |
| Pulmonary Disease, Chronic Obstructive | 3 | D029424 | ClinicalTrials |
| Tuberculosis, Multidrug-Resistant | 2 | D018088 | ClinicalTrials |
| Neoplasms | 2 | D009369 | ClinicalTrials |
| Meningitis | 2 | D008581 | ClinicalTrials |
| Neoplasms | 2 | D009369 | ClinicalTrials |
| Tuberculosis, Multidrug-Resistant | 2 | D018088 | ClinicalTrials |
| Parkinson Disease | 2 | D010300 | ClinicalTrials |
| Cholangitis | 2 | D002761 | ClinicalTrials |
| Muscle Spasticity | 2 | D009128 | ClinicalTrials |
| Lupus Erythematosus, Systemic | 1 | D008180 | ClinicalTrials |
| Dyspepsia | 1 | D004415 | ClinicalTrials |
| Cardiotoxicity | 1 | D066126 | ClinicalTrials |
| Influenza, Human | 1 | D007251 | ClinicalTrials |
| Lice Infestations | 1 | D010373 | ClinicalTrials |
| Hypotension, Orthostatic | 1 | D007024 | ClinicalTrials |
| Nausea | 1 | D009325 | ClinicalTrials |
| Schizophrenia | 1 | D012559 | ClinicalTrials |
| Acute Coronary Syndrome | 1 | D054058 | ClinicalTrials |
| Diabetes Mellitus, Type 2 | 1 | D003924 | ClinicalTrials |
| Hepatitis C | 1 | D006526 | ClinicalTrials |
| Lung Diseases | 1 | D008171 | ClinicalTrials |
| Amyotrophic Lateral Sclerosis | 1 | D000690 | ClinicalTrials |
| Carcinoma, Renal Cell | 1 | D002292 | ClinicalTrials |
| Arthritis, Rheumatoid | 1 | D001172 | ClinicalTrials |
| HIV Infections | 1 | D015658 | ClinicalTrials |
| Premature Birth | 1 | D047928 | ClinicalTrials |
| Fibromyalgia | 1 | D005356 | ClinicalTrials |
| Malaria, Vivax | 1 | D016780 | ClinicalTrials |
| Restless Legs Syndrome | 1 | D012148 | ClinicalTrials |
| Constipation | 1 | D003248 | ClinicalTrials |
| Alzheimer Disease | 1 | D000544 | ClinicalTrials |
| Epilepsy | 1 | D004827 | ClinicalTrials |
| Pain | 1 | D010146 | ClinicalTrials |
| Erectile Dysfunction | 1 | D007172 | ClinicalTrials |
| Lipid Metabolism Disorders | 1 | D052439 | ClinicalTrials |
| Lymphoma | 1 | D008223 | ClinicalTrials |
| Phenylketonurias | 1 | D010661 | ClinicalTrials |
| Asthma | 1 | D001249 | ClinicalTrials |
| Hypertension | 1 | D006973 | ClinicalTrials |
| Acquired Immunodeficiency Syndrome | 1 | D000163 | ClinicalTrials |
| Coronary Disease | 1 | D003327 | ClinicalTrials |
| Anemia | 1 | D000740 | ClinicalTrials |
| Psychotic Disorders | 1 | D011618 | ClinicalTrials |
| Diabetes Mellitus | 1 | D003920 | ClinicalTrials |
| Heart Failure | 1 | D006333 | ClinicalTrials |
| Hypoglycemia | 1 | D007003 | ClinicalTrials |
| Respiratory Tract Infections | 1 | D012141 | ClinicalTrials |
| Immune System Diseases | 1 | D007154 | ClinicalTrials |
| Osteomyelitis | 0 | D010019 | ClinicalTrials |
Related Entries
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 151096-09-2 |
| ChEBI | 63611 |
| ChEMBL | CHEMBL32 |
| DrugBank | DB00218 |
| DrugCentral | 1854 |
| EPA CompTox | DTXSID3048491 |
| FDA SRS | U188XYD42P |
| Human Metabolome Database | HMDB0014363 |
| Guide to Pharmacology | 10915 |
| PDB | MFX |
| PharmGKB | PA450555 |
| PubChem | 152946 |
| SureChEMBL | SCHEMBL24007 |
| ZINC | ZINC000003826253 |
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