Synonyms: | |
Status: | Phase 2 |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
UNII: | 7V3BY6G538 |
InChI Key | RXIUEIPPLAFSDF-CYBMUJFWSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C21H23N3O5 |
Molecular Weight | 397.43 |
AlogP | 2.9 |
Hydrogen Bond Acceptor | 7.0 |
Hydrogen Bond Donor | 3.0 |
Number of Rotational Bond | 7.0 |
Polar Surface Area | 111.88 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 29.0 |
Action | Mechanism of Action | Reference |
---|---|---|
ANTAGONIST | Interleukin-8 receptor A antagonist | PubMed PubMed ClinicalTrials PubMed |
Primary Target | |
---|---|
CXCR2 |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Membrane receptor
Family A G protein-coupled receptor
Peptide receptor (family A GPCR)
Chemokine receptor
CXC chemokine receptor
|
- | 0-680 | - | 4-5 | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Pulmonary Disease, Chronic Obstructive | 2 | D029424 | ClinicalTrials |
Asthma | 2 | D001249 | ClinicalTrials |
Psoriasis | 2 | D011565 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 473727-83-2 |
ChEMBL | CHEMBL2103864 |
FDA SRS | 7V3BY6G538 |
Guide to Pharmacology | 8497 |
PubChem | 71587828 |
SureChEMBL | SCHEMBL2024684 |
CAS NUMBER | 473727-83-2 |
ChEMBL | CHEMBL216981 |
FDA SRS | 7V3BY6G538 |
Guide to Pharmacology | 8497 |
PubChem | 71587828 |
SureChEMBL | SCHEMBL184744 |
ZINC | ZINC000100033051 |