NERISPIRDINE

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Synonyms:	HP-184 HP184 Nerispirdine Nerispirdine hydrochloride
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	G7M7YWO6CG

Structure


InChI Key	BTDHTARYCBHHPJ-UHFFFAOYSA-N
Smile	CCCN(c1ccncc1F)n1cc(C)c2ccccc21
InChI	InChI=1S/C17H18FN3/c1-3-10-20(17-8-9-19-11-15(17)18)21-12-13(2)14-6-4-5-7-16(14)21/h4-9,11-12H,3,10H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H18FN3
Molecular Weight	283.35
AlogP	4.16
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	0.0
Number of Rotational Bond	4.0
Polar Surface Area	21.06
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	21.0

Pharmacology

Action	Mechanism of Action	Reference
BLOCKER	Sodium channel alpha subunit blocker	Other PubMed

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Multiple Sclerosis	2	D009103	ClinicalTrials
Spinal Cord Injuries	2	D013119	ClinicalTrials

Related Entries

Scaffolds

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend network:

Indication

Mechanism of Action

Primary Target

Target Level

Cross References

Resources	Reference
CAS NUMBER	119229-65-1
ChEMBL	CHEMBL2107762
DrugBank	DB12714
EPA CompTox	DTXSID20152353
FDA SRS	G7M7YWO6CG
PubChem	3081185
SureChEMBL	SCHEMBL3842518

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