Synonyms: | |
Status: | Phase 2 |
Entry Type: | Small molecule |
Molecule Category: | Parent |
UNII: | QN4128B52A |
InChI Key | RFTSSZJZXOSICM-GRSHGNNSSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C20H19N3O |
Molecular Weight | 317.39 |
AlogP | 4.49 |
Hydrogen Bond Acceptor | 2.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 3.0 |
Polar Surface Area | 53.17 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 24.0 |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Ion channel
Other ion channel
Miscellaneous ion channel
Bcl-2 family
|
300 | 1110-1110 | - | 1110 | - | |
Membrane receptor
Family A G protein-coupled receptor
Small molecule receptor (family A GPCR)
Nucleotide-like receptor (family A GPCR)
Adenosine receptor
|
- | - | - | 5000 | - | |
Other cytosolic protein
|
500 | 2900-2900 | - | 1000-2000 | - | |
Unclassified protein
|
600 | - | - | 1000 | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Leukemia, Myeloid, Acute | 2 | D015470 | ClinicalTrials |
Small Cell Lung Carcinoma | 1 | D055752 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 803712-67-6 |
ChEMBL | CHEMBL408194 |
DrugBank | DB12191 |
FDA SRS | QN4128B52A |
Guide to Pharmacology | 11086 |
SureChEMBL | SCHEMBL631676 |
ZINC | ZINC000029052268 |