OGLEMILAST

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 67GXQ6WCC6

Structure
InChI Key OKFDRAHPFKMAJH-UHFFFAOYSA-N
Smile CS(=O)(=O)Nc1ccc2oc3c(OC(F)F)ccc(C(=O)Nc4c(Cl)cncc4Cl)c3c2c1
InChI
InChI=1S/C20H13Cl2F2N3O5S/c1-33(29,30)27-9-2-4-14-11(6-9)16-10(3-5-15(18(16)31-14)32-20(23)24)19(28)26-17-12(21)7-25-8-13(17)22/h2-8,20,27H,1H3,(H,25,26,28)

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H13Cl2F2N3O5S
Molecular Weight 516.31
AlogP 5.51
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 110.53
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 33.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Phosphodiesterase 4 inhibitor PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Asthma 2 D001249 ClinicalTrials
Pulmonary Disease, Chronic Obstructive 2 D029424 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 778576-62-8
ChEMBL CHEMBL4297520
DrugBank DB12375
FDA SRS 67GXQ6WCC6
PubChem 11387409
SureChEMBL SCHEMBL220245
ZINC ZINC000072266998
CONTENTS