OLINCIGUAT

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: PD5F4ZXD21

Structure
InChI Key YWQFJNWMWZMXRW-HXUWFJFHSA-N
Smile NC(=O)[C@](O)(CNc1nc(-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)ncc1F)C(F)(F)F
InChI
InChI=1S/C21H16F5N7O3/c22-12-4-2-1-3-11(12)9-33-16(14-5-6-36-32-14)7-15(31-33)18-28-8-13(23)17(30-18)29-10-20(35,19(27)34)21(24,25)26/h1-8,35H,9-10H2,(H2,27,34)(H,28,29,30)/t20-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H16F5N7O3
Molecular Weight 509.4
AlogP 2.51
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 8.0
Polar Surface Area 144.98
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 36.0

Pharmacology

Action Mechanism of Action Reference
POSITIVE ALLOSTERIC MODULATOR Soluble guanylate cyclase positive allosteric modulator PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Anemia, Sickle Cell 2 D000755 ClinicalTrials
Esophageal Achalasia 2 D004931 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1628732-62-6
ChEMBL CHEMBL4297616
DrugBank DB15238
FDA SRS PD5F4ZXD21
Guide to Pharmacology 10213
PubChem 90445883
SureChEMBL SCHEMBL16081945
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