OSILODROSTAT

Search structure
Synonyms:
Status: Approved (2020)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: H02CA02
UNII: 5YL4IQ1078

Structure
InChI Key USUZGMWDZDXMDG-CYBMUJFWSA-N
Smile N#Cc1ccc([C@H]2CCc3cncn32)c(F)c1
InChI
InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H10FN3
Molecular Weight 227.24
AlogP 2.43
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 1.0
Polar Surface Area 41.61
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 17.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 11 Cytochrome P450 family 11B Cytochrome P450 11B1
- 3-22 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 11 Cytochrome P450 family 11B Cytochrome P450 11B2
- 0-9 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 17 Cytochrome P450 family 17A Cytochrome P450 17A1
- 3981 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 19 Cytochrome P450 family 19A Cytochrome P450 19A1
- 856-6000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Pituitary ACTH Hypersecretion 3 D047748 ClinicalTrials
Cushing Syndrome 2 D003480 ClinicalTrials
Essential Hypertension 2 D000075222 ClinicalTrials
Hyperaldosteronism 2 D006929 ClinicalTrials
Hypertension 2 D006973 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 928134-65-0
ChEMBL CHEMBL3099695
DrugBank DB11837
DrugCentral 5384
EPA CompTox DTXSID40156570
FDA SRS 5YL4IQ1078
Guide to Pharmacology 8310
PDB YSY
PubChem 44139752
SureChEMBL SCHEMBL12460772
ZINC ZINC000072318114
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