PASIREOTIDE

Search structure
Synonyms:
Status: Approved (2012)
Entry Type: Protein
Molecule Category: Parent
ATC: H01CB05
UNII: 98H1T17066

Structure
InChI Key VMZMNAABQBOLAK-IXZCVAHUSA-N
Smile NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O
InChI
InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11,14-21,23-26,34,43,46-51,62H,12-13,22,27-33,35-36,59-60H2,(H,61,75)(H,63,71)(H,64,69)(H,65,73)(H,66,70)(H,67,72)/t43-,46-,47-,48+,49-,50-,51-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C58H66N10O9
Molecular Weight 1047.23
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Primary Target
SST1 receptor
SST2 receptor
SST3 receptor
SST5 receptor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Acromegaly 3 D000172 ClinicalTrials
Carcinoid Tumor 3 D002276 ClinicalTrials
Carcinoid Tumor 3 D002276 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Pituitary ACTH Hypersecretion 3 D047748 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Hyperglycemia 2 D006943 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Postoperative Complications 2 D011183 ClinicalTrials
Adenoma 2 D000236 ClinicalTrials
ACTH Syndrome, Ectopic 2 D000182 ClinicalTrials
Dumping Syndrome 2 D004377 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Carcinoma, Medullary 2 D018276 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Cushing Syndrome 2 D003480 ClinicalTrials
Pain 2 D010146 ClinicalTrials
Adenoma, Islet Cell 2 D007516 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Prostatic Neoplasms 1 D011471 ClinicalTrials
Digestive System Neoplasms 1 D004067 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials
Carcinoma, Intraductal, Noninfiltrating 1 D002285 ClinicalTrials
Neuroendocrine Tumors 1 D018358 ClinicalTrials
Carcinoma, Merkel Cell 1 D015266 ClinicalTrials

Related Entries

Scaffolds

Salt
Salt

Cross References

Resources Reference
CAS NUMBER 396091-73-9
ChEMBL CHEMBL3039583
FDA SRS 98H1T17066
Guide to Pharmacology 2018
PubChem 9941444
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