PEMIGATINIB

Search structure
Synonyms:
Status: Approved (2020)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L01EX20
UNII: Y6BX7BL23K

Structure
InChI Key HCDMJFOHIXMBOV-UHFFFAOYSA-N
Smile CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3[nH]c(CN4CCOCC4)cc3c21
InChI
InChI=1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3H3,(H,27,28)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H27F2N5O4
Molecular Weight 487.51
AlogP 3.66
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 83.16
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 35.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Fibroblast growth factor receptor 1 inhibitor FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Cholangiocarcinoma 4 D018281 ClinicalTrials
Myeloproliferative Disorders 2 D009196 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Urogenital Neoplasms 2 D014565 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 1513857-77-6
ChEMBL CHEMBL4297522
DrugBank DB15102
DrugCentral 5390
FDA SRS Y6BX7BL23K
Guide to Pharmacology 9767
PubChem 86705695
SureChEMBL SCHEMBL15556271
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