| Synonyms: | |
| Status: | Phase 3 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 2GWV496552 |
Structure
| InChI Key | SZFPYBIJACMNJV-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C25H52NO4P |
| Molecular Weight | 461.67 |
| AlogP | 6.99 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 20.0 |
| Polar Surface Area | 58.59 |
| Molecular species | ACID |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 31.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
AGC protein kinase group
AGC protein kinase AKT family
|
- | 5300-43350 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
CMGC protein kinase group
CMGC protein kinase MAPK family
CMGC protein kinase p38 subfamily
|
- | 1200 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Colorectal Neoplasms | 3 | D015179 | ClinicalTrials |
| Multiple Myeloma | 3 | D009101 | ClinicalTrials |
| Leukemia | 2 | D007938 | ClinicalTrials |
| Prostatic Neoplasms | 2 | D011471 | ClinicalTrials |
| Carcinoma, Renal Cell | 2 | D002292 | ClinicalTrials |
| Leukemia, Lymphocytic, Chronic, B-Cell | 2 | D015451 | ClinicalTrials |
| Lymphoma | 2 | D008223 | ClinicalTrials |
| Melanoma | 2 | D008545 | ClinicalTrials |
| Pancreatic Neoplasms | 2 | D010190 | ClinicalTrials |
| Head and Neck Neoplasms | 2 | D006258 | ClinicalTrials |
| Gastrointestinal Stromal Tumors | 2 | D046152 | ClinicalTrials |
| Waldenstrom Macroglobulinemia | 2 | D008258 | ClinicalTrials |
| Sarcoma | 2 | D012509 | ClinicalTrials |
| Kidney Neoplasms | 2 | D007680 | ClinicalTrials |
| Breast Neoplasms | 2 | D001943 | ClinicalTrials |
| Prostatic Neoplasms, Castration-Resistant | 2 | D064129 | ClinicalTrials |
| Colonic Neoplasms | 2 | D003110 | ClinicalTrials |
| Astrocytoma | 1 | D001254 | ClinicalTrials |
| Oligodendroglioma | 1 | D009837 | ClinicalTrials |
| Ovarian Neoplasms | 1 | D010051 | ClinicalTrials |
| Leukemia, Megakaryoblastic, Acute | 1 | D007947 | ClinicalTrials |
| Leukemia, Myeloid, Acute | 1 | D015470 | ClinicalTrials |
| Leukemia, Myeloid, Acute | 1 | D015470 | ClinicalTrials |
| Oligodendroglioma | 1 | D009837 | ClinicalTrials |
| Gliosarcoma | 1 | D018316 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Glioma | 1 | D005910 | ClinicalTrials |
| Brain Neoplasms | 1 | D001932 | ClinicalTrials |
| Carcinoma, Non-Small-Cell Lung | 1 | D002289 | ClinicalTrials |
| Myelodysplastic Syndromes | 1 | D009190 | ClinicalTrials |
| Leukemia, Biphenotypic, Acute | 1 | D015456 | ClinicalTrials |
| Leukemia, Monocytic, Acute | 1 | D007948 | ClinicalTrials |
| Leukemia, Myelomonocytic, Acute | 1 | D015479 | ClinicalTrials |
| Leukemia, Promyelocytic, Acute | 1 | D015473 | ClinicalTrials |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | 1 | D015464 | ClinicalTrials |
| Leukemia, Erythroblastic, Acute | 1 | D004915 | ClinicalTrials |
| Glioblastoma | 1 | D005909 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
Related Entries
MCS
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 157716-52-4 |
| ChEBI | 67272 |
| ChEMBL | CHEMBL372764 |
| DrugBank | DB06641 |
| EPA CompTox | DTXSID3048946 |
| FDA SRS | 2GWV496552 |
| Guide to Pharmacology | 7424 |
| PubChem | 148177 |
| SureChEMBL | SCHEMBL93872 |
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