PF-00446687

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 63P236Z73I

Structure
InChI Key WHPJOAUPIZDJNX-AGGGUQDCSA-N
Smile C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1
InChI
InChI=1S/C28H36F2N2O2/c1-18-14-31(15-19(2)28(18,34)20-9-7-6-8-10-20)26(33)24-17-32(27(3,4)5)16-23(24)22-12-11-21(29)13-25(22)30/h6-13,18-19,23-24,34H,14-17H2,1-5H3/t18-,19+,23-,24+,28-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C28H36F2N2O2
Molecular Weight 470.6
AlogP 4.78
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 43.78
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 34.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Melanocortin receptor 4 agonist Wikipedia PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Sexual Dysfunction, Physiological 2 D012735 ClinicalTrials
Erectile Dysfunction 2 D007172 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 862281-92-3
ChEMBL CHEMBL1090488
DrugBank DB12517
FDA SRS 63P236Z73I
SureChEMBL SCHEMBL13525566
ZINC ZINC000101338048
CONTENTS