PF-03463275

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 3U6T9EE6UX

Structure
InChI Key KYLOBHXXQOZRKK-FICVDOATSA-N
Smile CN1C[C@H]2[C@@H](C1)[C@@H]2CN(Cc1ccc(F)c(Cl)c1)C(=O)c1cn(C)cn1
InChI
InChI=1S/C19H22ClFN4O/c1-23-7-13-14(8-23)15(13)9-25(19(26)18-10-24(2)11-22-18)6-12-3-4-17(21)16(20)5-12/h3-5,10-11,13-15H,6-9H2,1-2H3/t13-,14+,15+

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H22ClFN4O
Molecular Weight 376.86
AlogP 2.66
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 5.0
Polar Surface Area 41.37
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 26.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Glycine transporter 1 inhibitor PubMed
Primary Target
GlyT1
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 8500 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- - - 12 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Schizophrenia 2 D012559 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL563251
DrugBank DB11993
FDA SRS 3U6T9EE6UX
Guide to Pharmacology 9057
ZINC ZINC000101270900
CONTENTS