| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 40497CY7Y3 |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C17H16ClN5O2 |
| Molecular Weight | 357.8 |
| AlogP | 2.98 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 95.06 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 25.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| BLOCKER | Sodium channel protein type X alpha subunit blocker |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Ion channel
Voltage-gated ion channel
Voltage-gated sodium channel
|
- | 190-700 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Toothache | 2 | D014098 | ClinicalTrials |
| Chronic Pain | 1 | D059350 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1079400-07-9 |
| ChEMBL | CHEMBL3544951 |
| FDA SRS | 40497CY7Y3 |
| PubChem | 57582353 |
CONTENTS