| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | CQ4M18RLJW |
Structure
| InChI Key | GEVVQZHMFVFGLN-HDJSIYSDSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C21H24N4O4 |
| Molecular Weight | 396.45 |
| AlogP | 2.85 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 118.64 |
| Molecular species | ACID |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 29.0 |
Pharmacology
| Primary Target | |
|---|---|
| diacylglycerol O-acyltransferase 1 |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Transferase
|
- | 8-90 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Obesity | 1 | D009765 | ClinicalTrials |
| Diabetes Mellitus, Type 2 | 1 | D003924 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1109276-89-2 |
| ChEMBL | CHEMBL1835919 |
| DrugBank | DB14887 |
| FDA SRS | CQ4M18RLJW |
| Guide to Pharmacology | 7829 |
| SureChEMBL | SCHEMBL1424359 |
| ZINC | ZINC000116139756 |
CONTENTS