| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 25U4N985O2 |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C18H12Cl2FN5O3S2 |
| Molecular Weight | 500.36 |
| AlogP | 5.15 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 122.99 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 31.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| BLOCKER | Sodium channel protein type IX alpha subunit blocker |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Auxiliary transport protein
Sodium channel auxiliary subunit beta family
|
- | 13 | - | - | - | |
|
Enzyme
Cytochrome P450
Cytochrome P450 family 2
Cytochrome P450 family 2C
Cytochrome P450 2C9
|
- | 299 | - | - | - | |
|
Ion channel
Voltage-gated ion channel
Voltage-gated sodium channel
|
- | 8.6-31 | - | - | - | |
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC22 family of organic cation and anion transporters
|
- | 3500 | - | - | - | |
|
Unclassified protein
|
- | 4.9 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Diabetic Neuropathies | 2 | D003929 | ClinicalTrials |
| Toothache | 2 | D014098 | ClinicalTrials |
| Erythromelalgia | 2 | D004916 | ClinicalTrials |
| Pain | 1 | D010146 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1235403-62-9 |
| ChEMBL | CHEMBL3545171 |
| FDA SRS | 25U4N985O2 |
| Guide to Pharmacology | 10723 |
| PubChem | 46840946 |
CONTENTS