PF-06273340

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: I136775ABW

Structure
InChI Key BPIWZDNVMQQBQX-UHFFFAOYSA-N
Smile CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc21
InChI
InChI=1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30)

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H22ClN7O3
Molecular Weight 479.93
AlogP 2.6
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 7.0
Polar Surface Area 148.91
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 34.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase IRAK family
- 2500 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase DDR family
- - - - 60
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Musk family
- 53 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- 53 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Trk family
- 3 - - -
Enzyme Oxidoreductase
- 2700 - - -
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D
- - - - 54
Enzyme Phosphodiesterase Phosphodiesterase 5 Phosphodiesterase 5A
- - - - 54
Enzyme Phosphodiesterase Phosphodiesterase 7 Phosphodiesterase 7B
- - - - 54
Enzyme Phosphodiesterase Phosphodiesterase 8 Phosphodiesterase 8B
- - - - 54
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 5200 - - -

Cross References

Resources Reference
CAS NUMBER 1402438-74-7
ChEMBL CHEMBL4212531
DrugBank DB12269
FDA SRS I136775ABW
PDB 6K4
PubChem 66571548
SureChEMBL SCHEMBL12984736
ZINC ZINC000203540977
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