PF-06459988

Search structure


Synonyms:	Pf-06459988
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	5IE92SK9EB

Structure


InChI Key	ODMXWZROLKITMS-RISCZKNCSA-N
Smile	C=CC(=O)N1C[C@H](COc2nc(Nc3cnn(C)c3)nc3[nH]cc(Cl)c23)[C@@H](OC)C1
InChI	InChI=1S/C19H22ClN7O3/c1-4-15(28)27-7-11(14(9-27)29-3)10-30-18-16-13(20)6-21-17(16)24-19(25-18)23-12-5-22-26(2)8-12/h4-6,8,11,14H,1,7,9-10H2,2-3H3,(H2,21,23,24,25)/t11-,14+/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H22ClN7O3
Molecular Weight	431.88
AlogP	2.13
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	7.0
Polar Surface Area	110.19
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	30.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family	-	7-5100	-	4-1600	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Carcinoma, Non-Small-Cell Lung	2	D002289	ClinicalTrials

Cross References

Resources	Reference
CAS NUMBER	1428774-45-1
ChEMBL	CHEMBL3786098
DrugBank	DB14768
FDA SRS	5IE92SK9EB
PubChem	71535003
SureChEMBL	SCHEMBL14800837
ZINC	ZINC000204947687

CONTENTS