PIBOSEROD

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 4UQ3S81B25

Structure
InChI Key KVCSJPATKXABRQ-UHFFFAOYSA-N
Smile CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1
InChI
InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H31N3O2
Molecular Weight 369.51
AlogP 3.67
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 46.5
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Serotonin 4 (5-HT4) receptor antagonist ClinicalTrials PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- - - - 67
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- 1 - 0-2 73-97

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Atrial Fibrillation 2 D001281 ClinicalTrials
Heart Failure 2 D006333 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 152811-62-6
ChEMBL CHEMBL356359
DrugBank DB04873
EPA CompTox DTXSID60165129
FDA SRS 4UQ3S81B25
Guide to Pharmacology 225
PubChem 177336
SureChEMBL SCHEMBL467339
ZINC ZINC000001537633
CONTENTS