PLITIDEPSIN

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L01XX57
UNII: Y76ID234HW

Structure
InChI Key UUSZLLQJYRSZIS-LXNNNBEUSA-N
Smile CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)C(C)=O)[C@@H](C)OC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)C(=O)[C@H](C(C)C)OC(=O)C[C@@H]1O
InChI
InChI=1S/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,36+,39-,40-,41-,42+,43-,44-,46+,47-,49-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C57H87N7O15
Molecular Weight 1110.36
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Elongation factor 1-alpha 2 inhibitor Other

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Multiple Myeloma 3 D009101 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Liposarcoma 2 D008080 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Primary Myelofibrosis 2 D055728 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 137219-37-5
ChEBI 90205
ChEMBL CHEMBL451930
DrugBank DB04977
FDA SRS Y76ID234HW
PubChem 9812534
SureChEMBL SCHEMBL13413427
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