PRX-03140

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Synonyms:	Prx-03140
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	7QGN8QXG7I

Structure


InChI Key	SCHKZZSVELPJKU-UHFFFAOYSA-N
Smile	CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21
InChI	InChI=1S/C19H27N3O3S/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H27N3O3S
Molecular Weight	377.51
AlogP	2.96
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	74.57
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	26.0

Pharmacology

Action	Mechanism of Action	Reference
PARTIAL AGONIST	Serotonin 4 (5-HT4) receptor partial agonist	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	17-58	-	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Alzheimer Disease	2	D000544	ClinicalTrials

Cross References

Resources	Reference
CAS NUMBER	869493-21-0
ChEMBL	CHEMBL3306918
DrugBank	DB05596
EPA CompTox	DTXSID90236013
FDA SRS	7QGN8QXG7I
PubChem	54677674
SureChEMBL	SCHEMBL2205618

CONTENTS