| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 378SU5NO8S |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C29H22Cl3NO4 |
| Molecular Weight | 554.86 |
| AlogP | 8.73 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 8.0 |
| Polar Surface Area | 72.56 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 37.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| AGONIST | Bile acid receptor FXR agonist |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transcription factor
Nuclear receptor
Nuclear hormone receptor subfamily 1
Nuclear hormone receptor subfamily 1 group H
Nuclear hormone receptor subfamily 1 group H member 4
|
4-1094 | - | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Non-alcoholic Fatty Liver Disease | 2 | D065626 | ClinicalTrials |
Related Entries
MCS
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1268244-88-7 |
| ChEMBL | CHEMBL3545113 |
| FDA SRS | 378SU5NO8S |
| PubChem | 118374999 |
CONTENTS