Synonyms: | |
Status: | Phase 2 |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
UNII: | JPX07AFM0N |
InChI Key | RDSACQWTXKSHJT-NSHDSACASA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C19H20F3IN2O5S |
Molecular Weight | 572.34 |
AlogP | 3.48 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 4.0 |
Number of Rotational Bond | 9.0 |
Polar Surface Area | 107.89 |
Molecular species | NEUTRAL |
Aromatic Rings | 2.0 |
Heavy Atoms | 31.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Dual specificity mitogen-activated protein kinase kinase 1 inhibitor | PubMed |
Primary Target | |
---|---|
mitogen-activated protein kinase kinase 1 | |
mitogen-activated protein kinase kinase 2 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Carcinoma, Hepatocellular | 2 | D006528 | ClinicalTrials |
Biliary Tract Neoplasms | 2 | D001661 | ClinicalTrials |
Neoplasms | 1 | D009369 | ClinicalTrials |
Neoplasms | 1 | D009369 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 923032-37-5 |
ChEMBL | CHEMBL1236682 |
DrugBank | DB06309 |
EPA CompTox | DTXSID40238961 |
FDA SRS | JPX07AFM0N |
Guide to Pharmacology | 7942 |
PDB | VRA |
PubChem | 44182295 |
SureChEMBL | SCHEMBL345333 |
ZINC | ZINC000039187987 |