RICOLINOSTAT

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: WKT909C62B

Structure
InChI Key QGZYDVAGYRLSKP-UHFFFAOYSA-N
Smile O=C(CCCCCCNC(=O)c1cnc(N(c2ccccc2)c2ccccc2)nc1)NO
InChI
InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H27N5O3
Molecular Weight 433.51
AlogP 4.13
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 11.0
Polar Surface Area 107.45
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Histone deacetylase 6 inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - - -3.643-8.33
Epigenetic regulator Eraser Histone deacetylase HDAC class I
- 16-390 - 123 -
Epigenetic regulator Eraser Histone deacetylase HDAC class IIa
- 7000-7220 - - -
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- 2.5-2600 - 1 95.3-104.97
Unclassified protein
- 37-51 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetic Neuropathies 2 D003929 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials
Lymphoma 1 D008223 ClinicalTrials
Multiple Myeloma 1 D009101 ClinicalTrials
Klatskin Tumor 1 D018285 ClinicalTrials
Peripheral Nervous System Diseases 1 D010523 ClinicalTrials
Hematologic Neoplasms 1 D019337 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 1 D015451 ClinicalTrials
Cholangiocarcinoma 1 D018281 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 1316214-52-4
ChEBI 95073
ChEMBL CHEMBL2364628
DrugBank DB12376
EPA CompTox DTXSID40157148
FDA SRS WKT909C62B
Guide to Pharmacology 7010
PDB AH4
PubChem 53340666
SureChEMBL SCHEMBL574580
ZINC ZINC000089630354
CONTENTS