| Synonyms: | |
| Status: | Approved (2020) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| ATC: | M09AX10 |
| UNII: | 76RS4S2ET1 |
Structure
| InChI Key | ASKZRYGFUPSJPN-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H23N7O |
| Molecular Weight | 401.47 |
| AlogP | 1.96 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 79.83 |
| Molecular species | BASE |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 30.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| POSITIVE MODULATOR | SMN2 pre-mRNA positive modulator | FDA |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Muscular Atrophy, Spinal | 4 | D009134 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1825352-65-5 |
| ChEMBL | CHEMBL4297528 |
| DrugBank | DB15305 |
| FDA SRS | 76RS4S2ET1 |
| Guide to Pharmacology | 11170 |
| PubChem | 118513932 |
| SureChEMBL | SCHEMBL17260852 |
CONTENTS