Synonyms: | |
Status: | Phase 2 |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
UNII: | DIH95YP7J3 |
InChI Key | FQJISUPNMFRIFZ-HXUWFJFHSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C25H31F2NO4 |
Molecular Weight | 447.52 |
AlogP | 3.9 |
Hydrogen Bond Acceptor | 4.0 |
Hydrogen Bond Donor | 3.0 |
Number of Rotational Bond | 11.0 |
Polar Surface Area | 78.79 |
Molecular species | ZWITTERION |
Aromatic Rings | 2.0 |
Heavy Atoms | 32.0 |
Action | Mechanism of Action | Reference |
---|---|---|
ANTAGONIST | Calcium sensing receptor antagonist | PubMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Membrane receptor
Family C G protein-coupled receptor
Ion receptor (family C GPCR)
Calcium sensing receptor
Calcium sensing receptor
|
- | 146 | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Osteoporosis | 2 | D010024 | ClinicalTrials |
Fractures, Bone | 2 | D050723 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 753449-67-1 |
ChEMBL | CHEMBL1198855 |
DrugBank | DB05255 |
EPA CompTox | DTXSID60892347 |
FDA SRS | DIH95YP7J3 |
Guide to Pharmacology | 9473 |
PubChem | 10345214 |
SureChEMBL | SCHEMBL3737849 |