| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | MZH0OM550M |
Structure
| InChI Key | WUILNKCFCLNXOK-CFBAGHHKSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H30O2S |
| Molecular Weight | 358.55 |
| AlogP | 6.9 |
| Hydrogen Bond Acceptor | 2.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 10.0 |
| Polar Surface Area | 37.3 |
| Molecular species | ACID |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 25.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | RAS inhibitor | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Transferase
|
- | 25500 | - | 2800 | 40 | |
|
Ion channel
Voltage-gated ion channel
Transient receptor potential channel
|
800-7000 | - | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Reference |
|---|---|---|
| Carcinoma, Non-Small-Cell Lung | Phase 2 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 162520-00-5 |
| ChEMBL | CHEMBL23293 |
| DrugBank | DB12681 |
| FDA SRS | MZH0OM550M |
| Guide to Pharmacology | 6281 |
| PubChem | 5469318 |
| SureChEMBL | SCHEMBL147320 |
| ZINC | ZINC000001650377 |
CONTENTS