Structure

InChI Key OUKYUETWWIPKQR-UHFFFAOYSA-N
Smile CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1
InChI
InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31)

Physicochemical Descriptors

Property Name Value
Molecular Formula C27H32ClN5O5
Molecular Weight 542.04
AlogP 3.94
Hydrogen Bond Acceptor 10.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 8.0
Polar Surface Area 90.44
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 38.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Tyrosine-protein kinase ABL inhibitor PubMed
Primary Target
ABL proto-oncogene 1, non-receptor tyrosine kinase
LCK proto-oncogene, Src family tyrosine kinase
SRC proto-oncogene, non-receptor tyrosine kinase
YES proto-oncogene 1, Src family tyrosine kinase

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Colonic Neoplasms 2 D003110 ClinicalTrials
Myositis Ossificans 2 D009221 ClinicalTrials
Lymphangioleiomyomatosis 2 D018192 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Breast Neoplasms, Male 2 D018567 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Alcohol Drinking 2 D000428 ClinicalTrials
Alzheimer Disease 2 D000544 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials
Alcoholism 1 D000437 ClinicalTrials
Pancreatic Neoplasms 1 D010190 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 379231-04-6
ChEMBL CHEMBL217092
DrugBank DB11805
EPA CompTox DTXSID90191355
FDA SRS 9KD24QGH76
Guide to Pharmacology 7731
PDB H8H
PubChem 10302451
SureChEMBL SCHEMBL41547
ZINC ZINC000024811973