SAVOLITINIB

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 2A2DA6857R

Structure
InChI Key XYDNMOZJKOGZLS-NSHDSACASA-N
Smile C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(-c3cnn(C)c3)nc21
InChI
InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H15N9
Molecular Weight 345.37
AlogP 1.88
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 91.61
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 26.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Hepatocyte growth factor receptor inhibitor PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family
- 2-676 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Pulmonary Disease, Chronic Obstructive 2 D029424 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Colorectal Neoplasms 1 D015179 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1313725-88-0
ChEMBL CHEMBL3334567
DrugBank DB12048
FDA SRS 2A2DA6857R
Guide to Pharmacology 9918
PDB V0L
PubChem 68289010
SureChEMBL SCHEMBL12489208
ZINC ZINC000149738712
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