Synonyms: | |
Status: | Phase 2 |
Entry Type: | Small molecule |
Molecule Category: | Parent |
UNII: | 7I279E1NZ8 |
InChI Key | OAVGBZOFDPFGPJ-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C25H22N6O2 |
Molecular Weight | 438.49 |
AlogP | 2.43 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 3.0 |
Polar Surface Area | 94.22 |
Molecular species | NEUTRAL |
Aromatic Rings | 4.0 |
Heavy Atoms | 33.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Protein kinase C (PKC) inhibitor | PubMed |
Primary Target | |
---|---|
protein kinase C alpha | |
protein kinase C beta | |
protein kinase C delta | |
protein kinase C epsilon | |
protein kinase C eta | |
protein kinase C theta |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Colitis, Ulcerative | 2 | D003093 | ClinicalTrials |
Uveitis, Posterior | 2 | D015866 | ClinicalTrials |
Psoriasis | 2 | D011565 | ClinicalTrials |
Lymphoma, Large B-Cell, Diffuse | 1 | D016403 | ClinicalTrials |
Lymphoma | 1 | D008223 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 425637-18-9 |
ChEBI | 90531 |
ChEMBL | CHEMBL565612 |
DrugBank | DB12369 |
FDA SRS | 7I279E1NZ8 |
Guide to Pharmacology | 7946 |
PDB | LW4 |
PubChem | 10296883 |
SureChEMBL | SCHEMBL2500835 |
ZINC | ZINC000003973984 |